Baylor handed Iowa State its worst loss in school history Saturday night in Waco, Texas, demolishing the Cyclones, 71-7.
The previous worst losses in ISU football history were by 63 points each: in 1997 at Nebraska (77-14) and in 1946 at Oklahoma (63-0).
The Cyclones are now 1-5 overall and 0-3 in the Big 12 and host Oklahoma State next Saturday.
Iowa State's only score at Baylor was a 27-yard touchdown pass from Grant Rohach to DeVondrick Nealy with 1:40 left to play in the game.
Baylor had 715 yards of total offense to just 173 for Iowa State.